Senior Scientist - In vitro Pharmacology - Gene Therapy

Company: Novartis Farmac--utica
Location: San Diego
Posted on: November 1, 2024

Job Description:

Senior Scientist - In vitro Pharmacology - Gene TherapyJob ID: REQ-10016392Jul 24, 2024USASummaryAbout the role:We are seeking a highly skilled and motivated Senior Scientist I to join our dynamic in vitro pharmacology team in San Diego dedicated to advancing gene therapy and siRNA for neurological and neuromuscular diseases. As a key member of our research programs, you will play a critical role in supporting various aspects of biomarker assay development, tissue sample processing, antibody screening campaigns, and monoclonal antibody isolation. Sounds exciting? Join us and make a difference.Your Key Responsibilities:

• Design, develop, and optimize biomarker assays essential for monitoring therapeutic efficacy and disease progression in neurological and neuromuscular gene therapy programs.
• Utilize expertise in ELISA, MSD, and Luminex assays to accurately measure biomarker levels in biological samples.
• Conduct tissue sample processing techniques to extract RNA, DNA, and proteins for downstream analysis.
• Conduct comprehensive analysis of gene expression utilizing techniques such as RT-ddPCR.
• Implement next-generation sequencing methodologies to assess gene expression profiles in relevant tissues.
• Lead antibody screening campaigns, including hybridoma generation, antibody selection, and validation.
• Isolate monoclonal antibodies using state-of-the-art techniques and platforms.
• Collaborate closely with cross-functional teams to integrate findings into the overall program strategy.
• Stay abreast of the latest scientific advancements and contribute to the continuous improvement of experimental protocols and techniques.Minimum Qualifications:
  • B.S. in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Immunology, Neuroscience) with 5+ years, MSc with 4+ years or Ph.D. with 2 years of industry experience.
  • Strong background in tissue sample processing techniques, including nucleic acid and protein extraction.
  • Experience in gene therapy biodistribution methods including ddPCR, RT-ddPCR.
  • Experience in cell isolation and characterization using flow cytometry, FACS.
  • Knowledge and understanding of next-generation sequencing methodologies and data analysis, including RNAseq, 10x Genomics. Hands-on experience a plus.
  • Knowledge and understanding of antibody screening campaigns, hybridoma generation, and monoclonal antibody isolation. Hands-on experience a plus.
  • Proficiency at problem-solving and ability to troubleshoot technical issues independently.
  • Strong interpersonal and communication skills, with the ability to collaborate effectively in a team environment.
  • Demonstrated track record of scientific innovation and productivity, as evidenced by publications and/or patents.
  • Expected travel: approximately 2%.
  • Prior experience in gene therapy research, particularly in neurological and neuromuscular diseases.
  • Familiarity with industry standards and technologies for biomarker assay development.
  • Ability to work in a fast-paced and growing team environment and to prioritize work from multiple projects. Must be highly reliable and goals/deadlines oriented.
  • Hands-on experience with automation and high-throughput screening platforms, a plus.Why Novartis:Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together?Commitment to Diversity & Inclusion:The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.Accessibility & Reasonable Accommodations:The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Division: Biomedical ResearchBusiness Unit: Pharma ResearchLocation: USASite: San DiegoCompany / Legal Entity: U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.
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Keywords: Novartis Farmac--utica, La Mesa , Senior Scientist - In vitro Pharmacology - Gene Therapy, Healthcare , San Diego, California